Effects of steroid hormones on lipid metabolism in sexual dimorphism: A Mendelian randomization study.

ABSTRACT:

Background

Although the role of steroid hormones in lipid levels has been partly discussed in the context of separate sexes, the causal relationship between steroid hormones and lipid metabolism according to sex has not been elucidated because of the limitations of observational studies. We assessed the relationship between steroid hormones and lipid metabolism in separate sexes using a two-sample Mendelian randomization (MR) study.

Methods

Instrumental variables for dehydroepiandrosterone sulfate (DHEAS), progesterone, estradiol, and androstenedione were selected. MR analysis was performed using inverse-variance weighted, MR-Egger, weighted median, and MR pleiotropy residual sum and outlier tests. Cochran's Q test, the MR-Egger intercept test, and leave-one-out analysis wer

SUBMITTER: Liang J 

PROVIDER: S-EPMC9886494 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature