A Western-style diet interacts with genetic variants of the LDL receptor to hyper-LDL cholesterolemia in Korean adults.

ABSTRACT:

Objective

To evaluate the association of genetic risk scores (GRS) of LDLR, APOB and proprotein convertase subtilisin-kexin type 9 (PCSK9) SNP and plasma LDL concentrations and to identify lifestyle interactions with the GRS in Korean middle-aged adults.

Design

Korean genome and epidemiology study (KoGES) was conducted to determine genetic variants and lifestyle factors, including nutrient intakes, in a retrospective hospital-based city cohort conducted by the Korean Center for Disease and Control during 2004-2013.

Settings

Hospitals in Korea.

Participants

Adults aged 40-77 years (n 28 445) without serious diseases.

Results

Subjects with the major alleles (risk allele) of LDLR rs1433099 and rs11557092, APOB rs13306194 and PCSK9 rs11583723 had higher plas

SUBMITTER: Park S 

PROVIDER: S-EPMC9886520 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature