Vitamin D genetic risk scores in multiple sclerosis.

ABSTRACT:

Background

Low serum 25(OH)D₃ (vD) is an environmental risk factor for multiple sclerosis (MS). Lower vD levels during early disease may be associated with long-term disability. Determinants of serum vD levels in healthy individuals include supplementation behaviour and genetic factors. These determinants have been less well studied in people with MS (pwMS).

Methods

We developed a vD-weighted genetic risk score (GRS) and validated this in 373,357 UK Biobank participants without MS. We measured serum 25(OH)D₃ and genotyped six vD-associated SNPs (rs12785878, rs10741657, rs17216707, rs10745742, rs8018720, rs2282679) in a cohort of pwMS (n = 315) with age and geographically matched controls (n = 232). We then assessed predictors of serum vD concentration i

SUBMITTER: Kuri A 

PROVIDER: S-EPMC9886624 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature