Rpl3l gene deletion in mice reduces heart weight over time.

ABSTRACT: Introduction: The ribosomal protein L3-like (RPL3L) is a heart and skeletal muscle-specific ribosomal protein and paralogue of the more ubiquitously expressed RPL3 protein. Mutations in the human RPL3L gene are linked to childhood cardiomyopathy and age-related atrial fibrillation, yet the function of RPL3L in the mammalian heart remains unknown. Methods and Results: Here, we observed that mouse cardiac ventricles express RPL3 at birth, where it is gradually replaced by RPL3L in adulthood but re-expressed with induction of hypertrophy in adults. Rpl3l gene-deleted mice were generated to examine the role of this gene in the heart, although Rpl3l ^-/- mice showed no overt changes in cardiac structure or function at baseline or after pressur

SUBMITTER: Grimes KM 

PROVIDER: S-EPMC9886673 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature