Longitudinal association of executive function and structural network controllability in the aging brain.

ABSTRACT: Executive function encompasses effortful cognitive processes that are particularly susceptible to aging. Functional brain networks supporting executive function-such as the frontoparietal control network and the multiple demand system-have been extensively investigated. However, it remains unclear how structural networks facilitate and constrain the dynamics of functional networks to contribute to aging-related executive function declines. We examined whether changes in structural network modal controllability-a network's ability to facilitate effortful brain state transitions that support cognitive functions-are associated with changes in executive function cross-sectionally and longitudinally. Diffusion-weighted imaging and neuropsychological testing were conducted at two time points (Ti

SUBMITTER: Tang R 

PROVIDER: S-EPMC9886719 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature