Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals.

ABSTRACT: The genetic roots of the diverse paces and shapes of ageing and of the large variations in longevity observed across the tree of life are poorly understood. Indeed, pathways associated with ageing/longevity are incompletely known, both in terms of their constitutive genes/proteins and of their molecular interactions. Moreover, there is limited overlap between the genes constituting these pathways across mammals. Yet, dedicated comparative analyses might still unravel evolutionarily conserved, important pathways associated with longevity or ageing. Here, we used an original strategy with a double evolutionary and systemic focus to analyse protein interactions associated with ageing or longevity during the evolution of five species of Opisthokonta. We ranked these proteins and interactions b

SUBMITTER: Teuliere J 

PROVIDER: S-EPMC9886728 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature