Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality.

ABSTRACT: Measures of biological age (BA) integrate information across organ systems to quantify "biological aging," i.e., inter-individual differences in aging-related health decline. While longevity and lifespan aggregate in families, reflecting transmission of genes and environments across generations, little is known about intergenerational continuity of biological aging or the extent to which this continuity may be modified by environmental factors. Using data from the Jerusalem Perinatal Study (JPS), we tested if differences in offspring BA were related to mortality in their parents. We measured BA using biomarker data collected from 1473 offspring during clinical exams in 2007-2009, at age 32 ± 1.1. Parental mortality was obtained from population registry data for the years 2004-2016. We fitt

SUBMITTER: Shapiro I 

PROVIDER: S-EPMC9886744 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature