Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening.

ABSTRACT: Hypertrophic carotid geometric phenotypes (h-CGP) are predictors of incident cardiovascular disease (CVD). While arterial aging is hypothesized as a contributor to this associated risk, the association of CGPs with chronological age is not clear. In this manuscript we examine whether hypertrophic CGPs represent accelerated biological, rather than chronological, aging by examining their association with carotid-femoral pulse wave velocity (PWV), the hallmark of arterial aging. We analyzed data from 5516 participants of the SardiNIA study with a wide range of age at baseline (20-101 years), and a median follow-up time of 13 years (mean 11.5 years; maximum 17.9 years). Baseline CGPs were defined based on the common carotid lumen diameter, wall thickness, and their ratio. Subject-specific rate

SUBMITTER: AlGhatrif M 

PROVIDER: S-EPMC9886763 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature