Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain.

ABSTRACT: Age-associated cognitive decline is common among otherwise healthy elderly people, even in the absence of Alzheimer's disease and neuron loss. Instead, white matter loss and myelin damage are strongly associated with cognitive decline. Myelin is subject to lifelong oxidative stress that damages the myelin sheath, which is repaired by cells of the oligodendrocyte lineage. This process is mediated by oligodendrocyte precursor cells (OPCs) that sense the damage and respond by proliferating locally and migrating to the region, where they differentiate into mature myelinating oligodendrocytes. In aging, extensive myelin damage, in combination with inefficient remyelination, leads to chronically damaged myelin and loss of efficient neuronal conduction. This study used the rhesus monkey model of

SUBMITTER: Dimovasili C 

PROVIDER: S-EPMC9886778 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature