Identification of hub genes involved in cisplatin resistance in head and neck cancer.

ABSTRACT:

Background

Cisplatin resistance is one of the major contributors to the poor survival rate among head and neck cancer (HNC) patients. Focusing on the protein-protein interaction rather than a single protein could provide a better understanding of drug resistance. Thus, this study aimed to identify hub genes in a complex network of cisplatin resistance associated genes in HNC chemotherapy via a series of bioinformatic tools.

Methods

The genes involved in cisplatin resistance were retrieved from the NCBI gene database using "head and neck cancer" and "cisplatin resistance" as key words. The human genes retrieved were analyzed for their interactions and enriched using the STRING database. The interaction between KEGG pathways and genes was visualized in Cytoscape 3.7.2. Further

SUBMITTER: Chaudhary RK 

PROVIDER: S-EPMC9886788 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature