Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Although a previous review illustrated the efficacy of melatonin receptor agonists (MRAs) in preventing delirium, some recent randomized controlled trials (RCTs) did not confirm these effects.

Objectives

This study systematically reviewed the efficacy, acceptability, and tolerability of MRAs for delirium prevention.

Materials and methods

We searched electronic databases, including Scopus, PubMed, CINAHL, and Controlled Trials Register, from their inception to February 20, 2022. The primary efficacy outcome was delirium incidence rate after MRA administration; relative risks (RRs), overall discontinuation, and discontinuation due to adverse events are also presented.

Results

The overall pooled incidence rates of delirium in MRA-treated and placebo-tre

SUBMITTER: Maneeton B 

PROVIDER: S-EPMC9886800 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature