Ionic Channels as Potential Targets for the Treatment of Autism Spectrum Disorder: A Review.

ABSTRACT: Autism spectrum disorder (ASD) is a neurological condition that directly affects brain functions and can culminate in delayed intellectual development, problems in verbal communication, difficulties in social interaction, and stereotyped behaviors. Its etiology reveals a genetic basis that can be strongly influenced by socio-environmental factors. Ion channels controlled by ligand voltage-activated calcium, sodium, and potassium channels may play important roles in modulating sensory and cognitive responses, and their dysfunctions may be closely associated with neurodevelopmental disorders such as ASD. This is due to ionic flow, which is of paramount importance to maintaining physiological conditions in the central nervous system and triggers action potentials, gene expression, and cell si

SUBMITTER: da Silva PR 

PROVIDER: S-EPMC9886809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature