Changes in John Cunningham Virus Index in Multiple Sclerosis Patients Treated with Different Disease-Modifying Therapies.

ABSTRACT:

Background

Progressive Multifocal Leukoencephalopathy (PML) is an opportunistic infection caused by John Cunningham virus (JCV) reactivation, potentially associated with natalizumab (NTZ) treatment for Multiple Sclerosis (MS). The anti-JCV antibodies titre (JCV index) increases during NTZ treatment; however, the effects of other disease-modifying therapies (DMTs) on the JCV index have not been fully explored.

Objective

The aim of the study was to evaluate changes in the JCV index during treatment with several DMTs.

Methods

This longitudinal study evaluated the JCV index before starting DMT (T0) and during treatment with DMT (T1).

Results

A total of 260 participants (65.4 % females, mean age 43 ± 11.3 ) were enrolled: 68 (26.2 %) treated with fingolimod (FTY), 6

SUBMITTER: Sgarlata E 

PROVIDER: S-EPMC9886813 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature