Stem Cell-based Therapeutic and Diagnostic Approaches in Alzheimer's Disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is a neurodegenerative impairment mainly recognized by memory loss and cognitive deficits. However, the current therapies against AD are mostly limited to palliative medications, prompting researchers to investigate more efficient therapeutic approaches for AD, such as stem cell therapy. Recent evidence has proposed that extensive neuronal and synaptic loss and altered adult neurogenesis, which is perceived pivotal in terms of plasticity and network maintenance, occurs early in the course of AD, which exacerbates neuronal vulnerability to AD. Thus, regeneration and replenishing the depleted neuronal networks by strengthening the endogenous repair mechanisms or exogenous stem cells and their cargoes is a rational therapeutic approach. Currently, s

SUBMITTER: Abdi S 

PROVIDER: S-EPMC9886816 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature