Perspective on mTOR-dependent Protection in Status Epilepticus.

ABSTRACT:

Background

The piriform cortex, known as area tempestas, has a high propensity to trigger limbic epileptic seizures. Recent studies on human patients indicate that a resection containing the piriform cortex produces a marked improvement in patients suffering from intractable limbic seizures. This calls for looking back at the pharmacological and anatomical data on area tempestas. Within the piriform cortex, status epilepticus can be induced by impairing the desensitization of AMPA receptors. The mechanistic target of rapamycin complex1 (mTORC1) is a promising candidate.

Objective

The present perspective aims to link the novel role of the piriform cortex with recent evidence on the modulation of AMPA receptors under the influence of mTORC1. This is based on recent evidence an

SUBMITTER: Biagioni F 

PROVIDER: S-EPMC9886823 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature