BACE1: A Key Regulator in Alzheimer's Disease Progression and Current Development of its Inhibitors.

ABSTRACT:

Background

Alzheimer's disease (AD) is a chronic neurodegenerative disease with no specific disease-modifying treatment. β-secretase (BACE1) is considered the potential and rationale target because it is involved in the rate-limiting step, which produces toxic Aβ₄₂ peptides that leads to deposits in the form of amyloid plaques extracellularly, resulting in AD.

Objective

This study aims to discuss the role and implications of BACE1 and its inhibitors in the management of AD.

Methods

We have searched and collected the relevant quality work from PubMed using the following keywords "BACE1", BACE2", "inhibitors", and "Alzheimer's disease". In addition, we included the work which discusses the role of BACE1 in AD and the recent work on its inhibitors.

Results<

SUBMITTER: Patel S 

PROVIDER: S-EPMC9886827 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature