The Role of High Mobility Group Box 1 (HMGB1) in Neurodegeneration: A Systematic Review.

ABSTRACT:

Background

High mobility group box 1 (HMGB1) protein is a damage-associated molecular pattern (DAMP) that plays an important role in the repair and regeneration of tissue injury. It also acts as a pro-inflammatory cytokine through the activation of toll-like receptor 4 (TLR4) and receptor for advanced glycation end products (RAGE), to elicit the neuroinflammatory response. HMGB1 may aggravate several cellular responses, which may lead to pathological inflammation and cellular death. Thus, there have been a considerable amount of research into the pathological role of HMGB1 in diseases. However, whether the mechanism of action of HMGB1 is similar in all neurodegenerative disease pathology remains to be determined.

Objective

Therefore, this systematic review aimed to criticall

SUBMITTER: Ikram FZ 

PROVIDER: S-EPMC9886836 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature