Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns.

ABSTRACT:

Introduction

Ficolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to premature birth.

Methods

546 premature neonates were included. The concentration of ficolin-2 in cord blood serum was determined by a sandwich TRIFMA method. FCN2 genetic variants were analysed with RFLP-PCR, allele-specific PCR, Sanger sequencing or allelic discrimination using TaqMan probes method.

Findings

Cord blood serum ficolin-2 concentration correlated positively with Apgar score and inversely with the length of hospitalisation and stay at Neonatal Intensive Care Unit (NICU). Multivariate logistic regres

SUBMITTER: Gajek G 

PROVIDER: S-EPMC9886859 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature