Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease.

ABSTRACT:

Introduction

The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear.

Methods

We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC).

Results

For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90-0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia

SUBMITTER: Pascoal TA 

PROVIDER: S-EPMC9886860 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature