Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities.

ABSTRACT: In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C₁₆Im) and 1-hexadecylpyridinium chloride (C₁₆PyrCl) against Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) infantum chagasi. Promastigotes of L. amazonensis and L. infantum chagasi were incubated with 0.1 to 100 μM of the compounds and eight of them demonstrated leishmanicidal activity after 48 h - C₁₀MImMeS (IC_{50 L. amazonensis} = 11.6), C₁₆MImPF₆(IC_{50 L. amazonensis} = 6.9), C₁₆MImBr (IC_{50 L. amazonensis} = 6), C₁₆M₂ImCl (IC

SUBMITTER: Baldissera FG 

PROVIDER: S-EPMC9886892 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature