A quadruple dissociation of reward-related behaviour in mice across excitatory inputs to the nucleus accumbens shell.

ABSTRACT: The nucleus accumbens shell (NAcSh) is critically important for reward valuations, yet it remains unclear how valuation information is integrated in this region to drive behaviour during reinforcement learning. Using an optogenetic spatial self-stimulation task in mice, here we show that contingent activation of different excitatory inputs to the NAcSh change expression of different reward-related behaviours. Our data indicate that medial prefrontal inputs support place preference via repeated actions, ventral hippocampal inputs consistently promote place preferences, basolateral amygdala inputs produce modest place preferences but as a byproduct of increased sensitivity to time investments, and paraventricular inputs reduce place preferences yet do not produce full avoidance behaviour. Th

SUBMITTER: Lind EB 

PROVIDER: S-EPMC9886947 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature