The Sapap3^-/- mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours.

ABSTRACT: Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and Tourette syndrome. Here, we meticulously analysed the behaviour of Sapap3 knockout mice, the recent rodent model predominantly used to study compulsive-like behaviours, and found that its behaviour is more complex than originally and persistently described. Indeed, we detected previously unreported elements of distinct pathologically repetitive behaviours, which do not form part of rodent syntactic cephalo-caudal self-grooming. These repetitive behaviours include sudden, rapid body and head/body twitches, resembling tic-like movements. We also observed t

SUBMITTER: Lamothe H 

PROVIDER: S-EPMC9886949 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature