CXCR5⁺PD-1⁺⁺ CD4⁺ T cells colonize infant intestines early in life and promote B cell maturation.

ABSTRACT: Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5⁺PD-1⁺⁺ CD4⁺ T cells (T_FH cells). We investigated the ontogeny of CXCR5⁺PD-1⁺⁺ CD4⁺ T cells in human intestines. While CXCR5⁺PD-1⁺⁺ CD4⁺ T cells were absent in fetal intestines, CXCR5⁺PD-1⁺⁺ CD4⁺ T cells increased after birth and were abundant in infant intestines, resulting in significant higher numbers compared to adults. These findings were supported by scRNAseq analyses, showing increased frequencies of CD4⁺ T cells with a T<

SUBMITTER: Jordan-Paiz A 

PROVIDER: S-EPMC9886971 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature