Psychological measures of stress and biomarkers of inflammation, aging, and endothelial dysfunction in breast cancer survivors on aromatase inhibitors.

ABSTRACT: The use of aromatase inhibitors (AIs) is associated with higher rates of cardiovascular events and lower endothelial function in breast cancer survivors. Psychosocial stress is associated with higher levels of inflammatory and aging markers, and lower endothelial function in otherwise healthy subjects. These associations among breast cancer survivors on AIs are not well defined. A cross-sectional study of 30 breast cancer survivors on AIs was performed to assess the associations between self-reported scores of psychosocial measures of depression, anxiety, and stress assessed by validated questionnaires with markers of inflammation (CRP; IL-6; IL-18), aging (p16^INK4a), and endothelial function (ICAM-1, EndoPAT ratio). Significant positive correlations were observed between psycho

SUBMITTER: Blaes AH 

PROVIDER: S-EPMC9886974 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature