Bioinformatic analysis identifies the immunological profile of turner syndrome with different X chromosome origins.

ABSTRACT:

Introduction

Turner syndrome (TS) is a chromosomal disorder that affects phenotypic females who have one intact X chromosome and complete or partial absence of the second sex chromosome in association with one or more clinical manifestations. However, the immunological profile of TS with different X chromosome origins is incompletely understood.

Methods

In this study, transcriptomic expression profiles of 26 TS (45,X) samples and 10 normal karyotype (46,XX) samples derived from GSE46687 cohort were employed. Differentially expressed immune-related genes (DEIRGs) between monosomy X TS patients with different X chromosome origins and normal females were investigated respectively. Subsequently, functional annotation, protein-protein interaction (PPI) network analysis, immunocyt

SUBMITTER: Qi X 

PROVIDER: S-EPMC9887020 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature