Dual targeting with ²²⁴Ra/²¹²Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach.

ABSTRACT: Metastases are the primary cause of death among cancer patients and efficacious new treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly cytotoxic may fulfill this critical need. The focus of this paper is to describe and explore a novel technology that may improve the therapeutic effect of targeted alpha therapy by combining two radionuclides from the same decay chain in the same solution. We hypothesize that the dual targeting solution containing bone-seeking ²²⁴Ra and cell-directed complexes of progeny ²¹²Pb is a promising approach to treat metastatic cancers with bone and soft tissue lesions as well as skeletal metastases of mixed lytic/osteoblastic nature. A novel liquid ²²⁴Ra/²¹²Pb-generator for rapid p

SUBMITTER: Juzeniene A 

PROVIDER: S-EPMC9887039 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature