Targeted inhibition of RBPJ transcription complex alleviates the exhaustion of CD8⁺ T cells in hepatocellular carcinoma.

ABSTRACT: Impaired function of CD8⁺ T cells in hepatocellular carcinoma (HCC) is an important reason for acquired resistance. Compared with single-target inhibitors, small-molecule compounds that could both inhibit tumor cells and alleviate T cell exhaustion are more promising to reduce resistance. In this study, we screened immunosuppressive targets in HCC by combining cancer-immunity cycle score with weighted gene co-expression network and system analysis. Through in vitro and in vivo validation experiments, we found that one of the screened molecules, recombination signal binding protein for immunoglobulin kappa J region (RBPJ), was negatively correlated with CD8⁺ T cell mediated killing function. More importantly, its transcription complex inhibitor RIN1 not only inhibited

SUBMITTER: Pan B 

PROVIDER: S-EPMC9887061 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature