Growth dynamics of brain metastases differentiate radiation necrosis from recurrence.

ABSTRACT:

Background

Radiation necrosis (RN) is a frequent adverse event after fractionated stereotactic radiotherapy (FSRT) or single-session stereotactic radiosurgery (SRS) treatment of brain metastases (BMs). It is difficult to distinguish RN from progressive disease (PD) due to their similarities in the magnetic resonance images. Previous theoretical studies have hypothesized that RN could have faster, although transient, growth dynamics after FSRT/SRS, but no study has proven that hypothesis using patient data. Thus, we hypothesized that lesion size time dynamics obtained from growth laws fitted with data from sequential volumetric measurements on magnetic resonance images may help in discriminating recurrent BMs from RN events.

Methods

A total of 101 BMs from different instituti

SUBMITTER: Ocana-Tienda B 

PROVIDER: S-EPMC9887079 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature