Diabetic retinopathy risk in patients with unhealthy lifestyle: A Mendelian randomization study.

ABSTRACT:

Purpose

This study aimed to investigate the causal association between unhealthy lifestyle factors and diabetic retinopathy (DR) risk and to determine better interventions targeting these modifiable unhealthy factors.

Design

Two-sample Mendelian randomization (MR) analysis was performed in this study. The inverse variance-weighted method was used as the primary method.

Method

Our study included 687 single-nucleotide polymorphisms associated with unhealthy lifestyle factors as instrumental variables. Aggregated data on individual-level genetic information were obtained from the corresponding studies and consortia. A total of 292,622,3 cases and 739,241,18 variants from four large consortia (MRC Integrative Epidemiology Unit [MRC-IEU], Genetic Investigation of Anthropom

SUBMITTER: Su Z 

PROVIDER: S-EPMC9887126 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature