HER2 status in recurrent/metastatic androgen receptor overexpressing salivary gland carcinoma patients.

ABSTRACT:

Background

Overexpression of human epidermal growth factor receptor type 2 (HER2) occurs in almost 25-30% of androgen receptor (AR)-positive salivary gland carcinomas (SGCs), notably salivary duct carcinoma (SDC) and adenocarcinoma not otherwise specified (NOS). In the last years, several studies have reported the clinical benefit of HER2 directed therapies in this setting. This work aims at describing the natural history of AR-positive recurrent/metastatic (R/M) SGC patients, based on HER2 amplification status.

Methods

Consecutive R/M AR-positive SGC patients accessing our Institution from 2010 to 2021 were analyzed. Descriptive statistics and survival analyses were performed to present the clinical characteristics of the selected patients and the outcomes, based on HER2 st

SUBMITTER: Cavalieri S 

PROVIDER: S-EPMC9887140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature