Prognostic implication of lactic dehydrogenase-to-albumin ratio in critically ill patients with acute kidney injury.

ABSTRACT:

Background

No studies have been published on the correlation between lactic dehydrogenase-to-albumin ratio (LAR) and poor prognosis of acute kidney injury (AKI) patients, warranting further research. This analysis sought to investigate the prognostic implication of LAR in critically ill patients with AKI.

Methods

The present study enrolled 11,046 and 5180 adults with AKI from the Medical Information Mart for Intensive Care III (MIMIC III) and MIMIC IV, respectively. Data from MIMIC IV were identified as the training cohort, and those from MIMIC III were identified as the validation cohort. We applied multivariate regression analysis to identify the link between LAR and all-cause mortality. Restricted cubic spline (RCS) was conducted to figure out the correlation between LAR

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9887249 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature