Fiber diameters and parallel patterns: proliferation and osteogenesis of stem cells.

ABSTRACT: Due to the innate extracellular matrix mimicking features, fibrous materials exhibited great application potential in biomedicine. In developing excellent fibrous biomaterial, it is essential to reveal the corresponding inherent fiber features' effects on cell behaviors. Due to the inevitable 'interference' cell adhesions to the background or between adjacent fibers, it is difficult to precisely reveal the inherent fiber diameter effect on cell behaviors by using a traditional fiber mat. A single-layer and parallel-arranged polycaprolactone fiber pattern platform with an excellent non-fouling background is designed and constructed herein. In this unique material platform, the 'interference' cell adhesions through interspace between fibers to the environment could be effectively ruled out b

SUBMITTER: Gu Z 

PROVIDER: S-EPMC9887345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature