Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.

ABSTRACT: Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH) than in uninfected populations. Objectives: To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature. Methods: Bronchial epithelial brushings from PLWH with and without COPD and HIV-uninfected adults with and without COPD (N = 76) were profiled for DNA methylation and gene expression. We evaluated global Alu and LINE-1 methylation and calculated the epigenetic age using the Horvath clock and the methylation telomere length estimator. To identify genome-wide differential DNA methylation and gene expression associated with HIV a

SUBMITTER: Hernandez Cordero AI 

PROVIDER: S-EPMC9887412 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature