SAOP: linking chemical stressors to adverse outcomes pathway networks.

ABSTRACT:

Motivation

Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making.

Results

With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the 'cytotoxitiy burst' (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP com

SUBMITTER: Aguayo-Orozco A 

PROVIDER: S-EPMC9887475 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature