Association of Maternal Depression During Pregnancy and Recent Stress With Brain Age Among Adult Offspring.

ABSTRACT:

Importance

Maternal mental health problems during pregnancy are associated with altered neurodevelopment in offspring, but the long-term relationship between these prenatal risk factors and offspring brain structure in adulthood remains incompletely understood due to a paucity of longitudinal studies.

Objective

To evaluate the association between exposure to maternal depression in utero and offspring brain age in the third decade of life, and to evaluate recent stressful life events as potential moderators of this association.

Design, setting, and participants

This cohort study examined the 30-year follow-up of a Czech prenatal birth cohort with a within-participant design neuroimaging component in young adulthood conducted from 1991 to 2022. Participants from the Eur

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC9887495 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature