Clinical and molecular significance of the RNA m⁶A methyltransferase complex in prostate cancer.

ABSTRACT: N⁶-methyladenosine (m⁶A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m⁶A modification. These proteins, and the m⁶A modification, are involved in the regulation of gene expression, RNA stability, splicing and translation. Given its role in these crucial processes, m⁶A has been implicated in many diseases, including in cancer development and progression. Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men and recent studies support a role for m⁶A in PCa. Despite this, the literature currently lacks an integrated analysis of the expression of key components of the m⁶A RNA

SUBMITTER: Lothion-Roy J 

PROVIDER: S-EPMC9887525 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature