Association of a FAM13A variant with interstitial lung disease in Japanese rheumatoid arthritis.

ABSTRACT:

Background

Interstitial lung disease (ILD) occasionally occurs in rheumatoid arthritis (RA) and confers a dismal prognosis. We previously reported that a single-nucleotide variant (SNV) of MUC5B was associated with ILD in RA. However, the pathogenesis of ILD in Japanese patients with RA could not be explained solely by this SNV because its frequency is extremely low in the Japanese population. Here, we examined whether a different idiopathic pulmonary fibrosis susceptibility SNV might be associated with ILD in Japanese patients with RA.

Methods

Genotyping of rs2609255 (G/T) in FAM13A was conducted in 208 patients with RA with ILD and 420 without chronic lung disease using TaqMan assays.

Results

A significant association with usual interstitial pneumonia

SUBMITTER: Higuchi T 

PROVIDER: S-EPMC9887688 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature