Combined anti-C1-INH and radiotherapy against glioblastoma.

ABSTRACT:

Background

A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. The complement system can function as a bridge between innate and adaptive immune responses. Combining radiotherapy and complement activating therapy is theoretically interesting.

Methods

Radiotherapy at 8 Gy × 2 was combined with treatment against C1-inhibitor (C1-INH), a potent inhibitor of activation of the classical pathway of the complement system. Anti-C1-INH was delivered as intratumoral injections. Fully immunocompetent Fischer 344 rats with NS1 glioblastoma tumors were treated. Survival was monitored as primary outcome. Models with either intracrani

SUBMITTER: Liljedahl E 

PROVIDER: S-EPMC9887755 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature