Characterization of large extracellular vesicles (L-EV) derived from human regulatory macrophages (Mreg): novel mediators in wound healing and angiogenesis?

ABSTRACT:

Background

Large extracellular vesicles (L-EV) with a diameter between 1 and 10 µm are released by various cell types. L-EV contain and transport active molecules which are crucially involved in cell to cell communication. We have shown that secretory products of human regulatory macrophages (Mreg) bear pro-angiogenic potential in-vitro and our recent findings show that Mreg cultures also contain numerous large vesicular structures similar to L-EV with so far unknown characteristics and function.

Aim of this study

To characterize the nature of Mreg-derived L-EV (L-EV_Mreg) and to gain insights into their role in wound healing and angiogenesis.

Methods

Mreg were differentiated using blood monocytes from healthy donors (N = 9) and L-EV_Mreg were isol

SUBMITTER: Albrecht M 

PROVIDER: S-EPMC9887800 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature