Novel cuproptosis-related long non-coding RNA signature to predict prognosis in prostate carcinoma.

ABSTRACT:

Background

Cuproptosis, an emerging form of programmed cell death, has recently been identified. However, the association between cuproptosis-related long non-coding RNA (lncRNA) signature and the prognosis in prostate carcinoma remains elusive. This study aims to develop the novel cuproptosis-related lncRNA signature in prostate cancer and explore its latent molecular function.

Methods

RNA-seq data and clinical information were downloaded from the TCGA datasets. Then, cuproptosis-related gene was identified from the previous literature and further applied to screen the cuproptosis-related differentially expressed lncRNAs. Patients were randomly assigned to the training cohort or the validation cohort with a 1:1 ratio. Subsequently, the machine learning algorithms (Lasso and

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9887873 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature