Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment.

ABSTRACT:

Background

Elucidating the unique immunoregulatory mechanisms in breast cancer microenvironment may help develop new therapeutic strategies. Some studies have suggested that hormone receptors also have immune regulatory functions, but their mechanisms are not fully understood. In this study, we have comprehensively analyzed the relationship between the expressions of estrogen (ER), progesterone (PgR), and androgen receptors (AR), and the immunological profile in breast cancer.

Methods

Using publicly available gene expression profile datasets, METABRIC and SCAN-B, the associations between the expressions of hormone receptors and the immune cell compositions in breast cancer tissue, estimated by CIBERSORTx algorithm, were analyzed. We histologically evaluated tumor-infiltratin

SUBMITTER: Hanamura T 

PROVIDER: S-EPMC9887885 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature