Mutations in troABCD against Copper Overload in a copA Mutant of Streptococcus suis.

ABSTRACT: Streptococcus suis is a major swine pathogen that is increasingly recognized as a porcine zoonotic pathogen that threatens the health of both pigs and humans. Metal homeostasis plays a critical role during the process of bacterial infection. In this study, RNA sequencing was used to identify potential candidate genes involved in the maintenance of intracellular copper homeostasis. CopA was identified as the primary copper exporter in S. suis. The copA deletion mutant strain was found to be more sensitive to copper and accumulated more intracellular copper than the wild-type (WT) parent strain. In addition, adding manganese increased the ability of S. suis to resist copper, and the manganese transporter, TroABCD, was involved in tolerance to copper. The copA deletion mutant st

SUBMITTER: Yang X 

PROVIDER: S-EPMC9888204 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature