Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection.

ABSTRACT: Increased demand for novel, highly effective vaccination strategies necessitates a better understanding of long-lived memory CD8 T cell differentiation. To achieve this understanding, we used the mouse model of acute lymphocytic choriomeningitis virus (LCMV) infection. We reexamined classical memory CD8 T cell subsets and performed in-depth, longitudinal analysis of their phenotype, transcriptional programming, and anatomic location within the spleen. All analyses were performed at multiple time points from 8 days to 1 year postinfection. Memory subsets are conventionally defined by their expression of KLRG1 and IL-7Rα, as follows: KLRG1⁺IL-7Rα^- terminal effectors (TEs) and KLRG1^-IL-7Rα⁺ memory precursors (MPs). But we also characterized a third

SUBMITTER: Gill AL 

PROVIDER: S-EPMC9888238 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature