Transcriptomic analysis of asthma and allergic rhinitis reveals CST1 as a biomarker of unified airways.

ABSTRACT:

Background

Allergic rhinitis (AR) is an important risk factor for the development of asthma. The "unified airway" theory considers the upper and lower airways as a morphological and functional whole. However, studies exploring biomarkers linking the upper and lower airways in allergic disease are lacking, which may provide insight into the mechanisms underlying AR comorbid asthma.

Purpose

To integrate bioinformatics techniques to explore biomarkers in airway allergic diseases, and to provide a molecular etiology profile for preventing the development of asthma in AR patients.

Methods

Biomarkers were screened by identifying key genes common between AR and asthma through WGCNA and differential gene analysis. GO and KEGG analyses were performed using DAVID. Immuno-infilt

SUBMITTER: Wang M 

PROVIDER: S-EPMC9888248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature