Cardiovascular risk factors, radiation therapy, and myocardial infarction among lymphoma survivors.

ABSTRACT:

Background

Mediastinal radiation is associated with increased risk of myocardial infarction (MI) among non-Hodgkin lymphoma (NHL) survivors.

Objective

To evaluate how preexisting cardiovascular risk factors (CVRFs) modify the association of mediastinal radiation and MI among a national population of NHL survivors with a range of CVRFs.

Material and methods

Using Danish registries, we identified adults diagnosed with lymphoma 2000-2010. We assessed MI from one year after diagnosis through 2016. We ascertained CVRFs (hypertension, dyslipidemia, and diabetes), vascular disease, and intrinsic heart disease prevalent at lymphoma diagnosis. We used multivariable Cox regression to test the interaction between preexisting CVRFs and receipt of mediastinal radiation on subseque

SUBMITTER: Salz T 

PROVIDER: S-EPMC9888465 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature