Cell-free, Dendritic Cell-mimicking Extracellular Blebs for Molecularly Controlled Vaccination.

ABSTRACT: Dendritic cells (DCs) are prime targets for vaccination and immunotherapy. However, limited control over antigen presentation at a desired maturation status in these plastic materials remains a fundamental challenge in efficiently orchestrating a controlled immune response. DC-derived extracellular vesicles (EVs) can overcome some of these issues, but have significant production challenges. Herein, we employ a unique chemically-induced method for production of DC-derived extracellular blebs (DC-EBs) that overcome the barriers of DC and DC-derived EV vaccines. DC-EBs are molecular snapshots of DCs in time, cell-like particles with fixed stimulatory profiles for controlled immune signalling. DC-EBs were produced an order of magnitude more quickly and efficiently than conventional EVs and dis

SUBMITTER: Thone MN 

PROVIDER: S-EPMC9888466 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature