Antimicrobial Nitric Oxide-Releasing Electrospun Dressings for Wound Healing Applications.

ABSTRACT: Nonhealing and chronic wounds represent a major problem for the quality of life of patients and have cost implications for healthcare systems. The pathophysiological mechanisms that prevent wound healing are usually multifactorial and relate to patient overall health and nutrition, vascularity of the wound bed, and coexisting infection/colonization. Bacterial infections are one of the predominant issues that can stall a wound, causing it to become chronic. Successful wound healing often depends on weeks or months of antimicrobial therapy, but this is problematic given the rise in multidrug-resistant bacteria. As such, alternatives to antibiotics are desperately needed to aid the healing of chronic, and even acutely infected wounds. Nitric oxide (NO) kills bacteria through a variety of mech

SUBMITTER: Li M 

PROVIDER: S-EPMC9888637 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature