Partially Recursively Induced Structured Moderation (PRISM) for modeling racial differences in endometrial cancer survival.

ABSTRACT:

Purpose

Health disparities are driven by a complex interplay of determinants operating across multiple levels of influence. However, while recognized conceptually, much disparities research fails to capture this inherent complexity in study focus and/or design; little of such work accounts for the interplay across the multiple levels of influence from structural (contextual) to biological or clinical. We developed a novel modeling framework that addresses these challenges and provides new insights.

Methods

We used data from the Florida Cancer Data System on endometrial cancer patients and geocoded-derived social determinants of health to demonstrate the applicability of a new modeling paradigm we term PRISM regression. PRISM is a new highly interpretable tree-based modeling

SUBMITTER: Rao JS 

PROVIDER: S-EPMC9888685 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature