Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies.

ABSTRACT: Use of rigorous study design methods and transparent reporting in publications are 2 key strategies proposed to improve the reproducibility of preclinical research. Despite promotion of these practices by funders and journals, assessments suggest uptake is low in preclinical research. Thirty preclinical scientists were interviewed to better understand barriers and enablers to rigorous design and reporting. The interview guide was informed by the Theoretical Domains Framework, which is a framework used to understand determinants of current and desired behavior. Four global themes were identified; 2 reflecting enablers and 2 reflecting barriers. We found that basic scientists are highly motivated to apply the methods of rigorous design and reporting and perceive a number of benefits to their

SUBMITTER: Lalu MM 

PROVIDER: S-EPMC9888705 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature