Efficacy and safety of ursodeoxycholic acid in children with cholestasis: A systematic review and meta-analysis.

ABSTRACT:

Objectives

Ursodeoxycholic acid (UDCA) is the main therapeutic drug for cholestasis, but its use in children is controversial. We conducted this study to evaluate the efficacy and safety of ursodeoxycholic acid in children with cholestasis.

Methods

We searched Medline (Ovid), Embase (Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), CNKI, WanFang Data and VIP from the establishment of databases to July 2022. Eligible studies included Chinese or English randomized controlled trials (RCTs) comparing the efficacy and safety of no UDCA (placebo or blank control) and UDCA in children with cholestasis. This study had been registered with PROSPERO (CRD42022354052).

Results

A total of 32 RCTs proved eligible, which included 2153 patients. The results of meta-an

SUBMITTER: Huang L 

PROVIDER: S-EPMC9888709 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature